Endocrine Abstracts

The incidence of gastric neuroendocrine tumors (GNT) is increasing, what can be explained by the increased detection caused by the common use of the endoscopy and the pervasive use of acid suppressive therapy leading to enterochromatofine like cells proliferation. There are numerous new diagnostic/therapeutic GNT methods in use like: EUS, SRS, somatostatin therapy and 90Y/177Lu-DOTA-TATE radiotherapy.Materials and methods: In 1998–2008 37 patients w...

Background: NETs are rare tumours arising from dispersed neuroendocrine system. Nevertheless, their estimated prevalence increased lately, mostly due to progress in imaging, biochemical and histopathological diagnostics.The aim of the study was to present the characteristics of the NETs patient surveyed in our Endocrinology Department since 2000.Material and methods: One hundred and fifty-eight patients (males – 42.4%, females...

Despite a wide spectrum of imaging diagnostics, GEP-NETs often stay undetectable until the time of dissemination. Removing of a primary tumour together with disseminated lymph nodes even with the presence of liver metastases is the most appropriate treatment to delay progression of the disease. SRS followed by RGS gives a possibility to detect occult GEP-NET intra-opratively. 99mTc-HYNIC/EDDA-octreotate, a somatostatin analogue with high affinity to sst2 was applied...

Neuroendocrine tumours (NETs) are rare neoplasm arising from dispersed endocrine system. Their incidence is estimated to be five cases per 100 000 population, although the true incidence may be higher as the consequence of often oligosymptomatic course of disease and indolent behaviour of NETs. The most typical localization of NETs is gastrointestinal tract and bronchi. However they may develop in every organ of the body containing neuroendocrine cells. The diagnosis of NET is...

The pattern of SSTRs expression in neuroendocrine neoplasms determines the possibility of the detection of the primary tumour and distant metastases, the application of radio-guided surgery (RGS) and the outcome of the treatment with itrium or lutetium labeled somatostatin analogues. The frequency and expression pattern of each subtype of SSTRs not only vary considerably in different NET but also in each patient.The aim of the study was to assess the SST...

Pancreatic NETs often cause difficulties in imaging diagnostics and optimal diagnostic algorithm is searched for. According to the latest reports MDCT sensitivity amounts 60-90%, MR: 80-90%, SRS: 62-100%, EUS: 70-90%.Aim: Assessment of the usefulness of 99 mTc-EDDA/HYNIC-octreotae scintigraphy in detection of primary and metastatic tumours of pancreatic NET in comparison to CT, EUS and IOUS and evaluation of the impact of scintigraphic results...